Methyl benzo[d]thiazole-6-carboxylate → 6-(Aminomethyl)benzothiazole

반응식

[S:1]1[C:5]2[CH:6]=[C:7]([C:10](OC)=O)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.Cl.S1C2C=C[N:20]=CC=2C=C1CN>>[S:1]1[C:5]2[CH:6]=[C:7]([CH2:10][NH2:20])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

참가 물질

반응물 2

HCID 595763Methyl benzo[d]thiazole-6-carboxylate

HCID 67306703Thieno[3,2-c]pyridin-2-ylmethanamine hydrochloride

생성물 1

HCID 450770136-(Aminomethyl)benzothiazole

실험 절차

Intermediate T was prepared from methyl benzo[d]thiazole-6-carboxylate (T-2) following similar procedures for synthesizing intermediate D from D-2, as described above. MS (m/z): 165 (M+1)+.

출처 및 근거

ORD 기록: ord-886d80be1a2f4cfcba6f9717aef525e7
출처 데이터셋: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08507487B2

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