Tetrahydrofuran → 4-(Methylamino)-2-(methylthio)pyrimidine-5-carbonitrile
반응식
CN.CO.[CH2:5]([N:7](CC)CC)C.O1CCCC1.Cl[C:18]1[C:23]([C:24]#[N:25])=[CH:22][N:21]=[C:20]([S:26][CH3:27])[N:19]=1>O>[CH3:5][NH:7][C:18]1[C:23]([C:24]#[N:25])=[CH:22][N:21]=[C:20]([S:26][CH3:27])[N:19]=1참가 물질
6
실험 절차
3 ml of a methylamine-methanol solution, and 246 mg of triethylamine were added to a tetrahydrofuran (10 mL) solution containing 150 mg of 4-chloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile, and the mixture was stirred for 30 minutes at room temperature. After adding water, the solution was extracted with ethyl acetate, and dried with anhydrous magnesium sulfate. After concentration, 134 mg of a white solid was obtained as a subject compound.
후처리
- extractionthe solution was extracted with ethyl acetate
- dry with materialdried with anhydrous magnesium sulfate
- concentrationAfter concentration
출처 및 근거
- ORD 기록
- ord-9f8fa8b662f9434ba8143bae925f26f2
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08507505B2
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