Tetrabutylammonium Fluoride → {3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol

HRID 1891239

반응식

HRID 1891239 반응식
[Si]([O:8][CH2:9][C:10]1[CH:11]=[C:12]([C:16]2[CH:17]=[CH:18][C:19]3[N:20]([C:22]([CH3:33])=[C:23]([C:25]4[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=4[F:32])[N:24]=3)[CH:21]=2)[CH:13]=[CH:14][CH:15]=1)(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[F:32][C:26]1[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:25]=1[C:23]1[N:24]=[C:19]2[CH:18]=[CH:17][C:16]([C:12]3[CH:11]=[C:10]([CH2:9][OH:8])[CH:15]=[CH:14][CH:13]=3)=[CH:21][N:20]2[C:22]=1[CH3:33]

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 698104776-[3-(tert-Butyldimethylsilanyloxymethyl)phenyl]-2-(2,4-difluorophenyl)-3-methylimidazo[1,2-a]pyridine

생성물 1

HCID 44233767{3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol수율 82.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

210 mg of 6-[3-(tert-butyldimethylsilanyloxymethyl)phenyl]-2-(2,4-difluorophenyl)-3-methylimidazo[1,2-α]pyridine in 5 ml of tetrahydrofuran are placed in a round-bottomed flask and 240 mg of tetrabutylammonium fluoride are added thereto. The mixture is stirred at ambient temperature for 48 h. The reaction mixture is then concentrated under reduced pressure. The residue is purified by silica gel chromatography, elution being carried out with a dichloromethane/methanol mixture. 130 mg of compound are obtained.

후처리

  1. concentrationThe reaction mixture is then concentrated under reduced pressure
  2. customThe residue is purified by silica gel chromatography, elution

출처 및 근거

ORD 기록
ord-5127ccf1189a46d58465fd58b87a1788
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507520B2

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