Triethylamine → HCID 43401847, 화합물

HRID 1891268노트

반응식

HRID 1891268 반응식
[Br:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][NH:7][CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH:21]1([NH2:24])[CH2:23][CH2:22]1.C1CN([P+](ON2N=NC3C=CC=CC2=3)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F>ClCCl.CCOC(C)=O.CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:7][CH2:8][C:9]([NH:24][CH:21]2[CH2:23][CH2:22]2)=[O:11])=[CH:12][CH:13]=1

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 69828CyclopropylamineHCID 2724699PyBOPHCID 28354373N-[(4-Bromophenyl)methyl]glycine

생성물 1

HCID 43401847HCID 43401847, 화합물수율 30.4%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 21584119Ethylacetate methanol용매

실험 절차

To a suspension of 2-(4-bromobenzylamino)acetic acid (7H2) (109 mmol, 26.5 g) in dichloromethane (300 ml) was added triethylamine (326 mmol, 33.0 g), cyclopropylamine (7H3) (163 mmol, 9.30 g) and PyBOP (109 mmol, 56.5 g). The suspension was stirred at room temperature overnight before concentration and purification on silica eluting with EtOAc/MeOH 1:0 to 9:1 to give 2-(4-bromobenzylamino)-N-cyclopropylacetamide (7H4) 9.38 g (30.3%); 1H NMR (400 MHz, MeODd4) 7.57 (d, 2H) 7.34 (d, 2H) 4.13 (m, 2H) 3.63 (s, 2H) 2.68 (m 1H) 0.76 (m, 2H) 0.56 (m, 2H).

출처 및 근거

ORD 기록
ord-7910d7f7306b4ee59c5944fdde9c0e37
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507521B2

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