Benzyl Bromide → 2,5-Dibenzyl-4,6-dioxooctahydropyrrolo[3,4-c]pyridine

HRID 1892노트

반응식

HRID 1892 반응식
C([O-])([O-])=O.[K+].[K+].[CH2:7]([N:14]1[CH2:22][CH:21]2[CH:16]([C:17](=[O:24])[NH:18][C:19](=[O:23])[CH2:20]2)[CH2:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH2:25](Br)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>CN(C=O)C.C(OCC)(=O)C>[CH2:7]([N:14]1[CH2:22][CH:21]2[CH:16]([C:17](=[O:24])[N:18]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:19](=[O:23])[CH2:20]2)[CH2:15]1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

참가 물질

6

반응물 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 196912212-Benzyl-4,6-dioxooctahydropyrrolo[3.4-c]pyridine

생성물 1

HCID 196913492,5-Dibenzyl-4,6-dioxooctahydropyrrolo[3,4-c]pyridine수율 111.4%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

To a mixture of 905 mg of K2CO3 and 400 mg of the compound from step 457b in 5 mL of DMF was added 308 mg of benzyl bromide, and the reaction mixture was stirred at room temperature under N2 for 6.5 hours. The mixture was diluted with ethyl acetate, which was washed with water and brine, dried and concentrated to give 610 mg of the title compound.

후처리

  1. washwas washed with water and brine
  2. customdried
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-eb07eb00507a464db46f471df4d8364d
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05726182

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