Dimethylformamide → HCID 14990310, 화합물

HRID 1892078노트

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HRID 1892078 반응식
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].CN(C=O)C.[CH2:12]([C:17]1[CH:22]=[CH:21][C:20](/[C:23](/C)=[CH:24]/C(O)=O)=[CH:19][CH:18]=1)[CH2:13][CH2:14][CH2:15][CH3:16]>ClCCl>[CH2:12]([C:17]1[CH:22]=[CH:21][C:20](/[C:23](/[CH3:24])=[CH:1]/[C:2]([Cl:4])=[O:3])=[CH:19][CH:18]=1)[CH2:13][CH2:14][CH2:15][CH3:16]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 6083612(E)-3-(4-pentylphenyl)but-2-enoic acid

생성물 1

HCID 14990310HCID 14990310, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Oxalyl chloride (3.2 mL, 36.60 mmol) and DMF (50 μL) were added drop wise to a solution of compound 1003 (5.0 g, 21.52 mmol) in dichloromethane (100 mL) at 0° C. The reaction solution was warmed up to room temperature and stirred for 4 hours. The reaction mixture was concentrated in vacuum and the residue was dried under hi-vacuum for 3 hours. The crude product was used in the next step without further purification.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuum
  2. customthe residue was dried under hi-vacuum for 3 hours
  3. customThe crude product was used in the next step without further purification

출처 및 근거

ORD 기록
ord-d1071c2591134443bbc82c1b96380fd9
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507647B2

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