Triethylamine → 1-Heptyl-4-isocyanatobenzene

HRID 1892094

반응식

HRID 1892094 반응식
[CH2:1]([C:8]1[CH:16]=[CH:15][C:11](C(O)=O)=[CH:10][CH:9]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].CC[N:19]([CH2:22]C)CC.C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:31])C=CC=CC=1>C1(C)C=CC=CC=1>[CH2:1]([C:8]1[CH:9]=[CH:10][C:11]([N:19]=[C:22]=[O:31])=[CH:15][CH:16]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 170036Benzoic acid, 4-heptyl-HCID 199401P,P-Diphenylphosphinic azide

생성물 1

HCID 594097981-Heptyl-4-isocyanatobenzene

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a degassed solution of 4-heptylbenzoic acid (3.0 g, 13.6 mmol) in anhydrous toluene (30 mL) and Et3N (3 mL, 21.5 mmol), was added diphenyl phosphoryl azide (2 mL, 9.3 mmol) dropwise. After completion of the addition, the reaction mixture was heated to reflux and stirred for 2 hours. The mixture was concentrated to dryness under reduced pressure to give the product, 1-heptyl-4-isocyanatobenzene (79), as an oil, which was used directly in the next reaction without further purification.

후처리

  1. additionAfter completion of the addition
  2. temperaturethe reaction mixture was heated
  3. temperatureto reflux
  4. concentrationThe mixture was concentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-fb51dda54e704621bcbae391cff51a49
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507647B2

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