Methanesulfonamide → N-(Diphenoxymethylene)-methanesulfonamide
반응식
Cl[C:2](Cl)([O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:18][S:19]([NH2:22])(=[O:21])=[O:20]>CCOC(C)=O>[CH3:18][S:19]([N:22]=[C:2]([O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:21])=[O:20]참가 물질
4
실험 절차
Dichlorodiphenoxymethane (2 g, 7.46 mmol) and methylsulfonamide (1.56 g, 16.41 mmol) were dissolved in EtOAc (15 ml) and heated to reflux for 12 hours. The mixture was allowed to cool and was concentrated under vacuum. Purification of the crude mixture by flash chromatography (20% EtOAc/hexanes) afforded diphenyl methylsulfonylcarbonimidate (0.75 g, 2.59 mmol, 35%).
후처리
- temperatureheated
- temperatureto reflux for 12 hours
- temperatureto cool
- concentrationwas concentrated under vacuum
- customPurification of the crude mixture by flash chromatography (20% EtOAc/hexanes)
출처 및 근거
- ORD 기록
- ord-ba0a139c0cc145c4b92af88b1ebbac74
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08507672B2
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