참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | 4-Methoxy-2-nitrobenzoic acid | HCID 288657 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Methyl 4-methoxy-2-nitrobenzoate | HCID 17733355 | 100% |
반응 단계
To a solution of 4-methoxy-2-nitrobenzoic acid (10.0 g, 50.7 mmol) in DMF (200 mL) at 0° C. was added DBU (15.2 mL, 101 mmol) followed by iodomethane (9.47 mL, 152 mmol). The reaction mixture was allowed to stir at 0° C. for 15 min then at rt overnight. The mixture was poured into water and extracted with EtOAc. The organic solutions were combined, washed with brine and dried over MgSO4. The residue was purified by column chromatography to give methyl 4-methoxy-2-nitrobenzoate (50.7 mmol, 85%) as a yellow solid. LCMS (FA): m/z=212.1 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08507667B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_08 |
|---|
| ORD ID | ord-4a33469655464feba4418f0ec4632239 |
|---|
| 출처 메모 | uspto-grants-2013_08 |
|---|
