Hydrazine → 2-Hydrazinyl-4-isopropyl-1,8-naphthyridine

반응식

Cl[C:2]1[CH:11]=[C:10]([CH:12]([CH3:14])[CH3:13])[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:15][NH2:16]>>[NH:15]([C:2]1[CH:11]=[C:10]([CH:12]([CH3:14])[CH3:13])[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1)[NH2:16]

참가 물질

반응물 2

HCID 9321Hydrazine

HCID 866692872-Chloro-4-isopropyl-1,8-naphthyridine

생성물 1

HCID 670830372-Hydrazinyl-4-isopropyl-1,8-naphthyridine수율 92%

실험 절차

A solution of chloro-4-isopropyl-1,8-naphthyridine (690 mg, 3.4 mmol) in NH2NH2 was reacted as outlined in Scheme 1 above to give the desired title compound (620 mg, 92%). Spectroscopic data: 1H NMR (300 MHz, CDCl3) δ ppm 1.35 (d, J=6.74 Hz, 6 H) 3.45-3.59 (m, 1 H) 6.70 (br. s., 1 H) 7.21 (dd, J=8.06, 4.54 Hz, 1 H) 8.19 (d, J=7.62 Hz, 1 H) 8.79 (br. s., 1 H).

출처 및 근거

ORD 기록: ord-7768132dd7124a0c861db46b10752b10
출처 데이터셋: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08507682B2

반응 노트

불러오는 중…