Triethylamine → Methyl (z)-2-((((1-aminoethylidene)amino)oxy)carbonyl)isonicotinate
반응식
Cl[C:2]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][N:13]=1)[C:7]([O:9][CH3:10])=[O:8])=[O:3].[OH:14]/[N:15]=[C:16](\[NH2:18])/[CH3:17].C(N(CC)CC)C>ClCCl>[NH2:18]/[C:16](=[N:15]\[O:14][C:2]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][N:13]=1)[C:7]([O:9][CH3:10])=[O:8])=[O:3])/[CH3:17]참가 물질
5
실험 절차
To a solution of methyl 2-(chlorocarbonyl)isonicotinate in dichloromethane (500 mL) was added (Z)—N′-hydroxyacetimidamide and triethylamine, keeping the temperature at 25-30° C. for 1 day. The reaction was concentrated in vacuo to afford (Z)-methyl 2-((1-aminoethylideneaminooxy)carbonyl)isonicotinate as a yellow solid.
후처리
- customat 25-30° C.
- customfor 1 day
- concentrationThe reaction was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-af8a40a6eebc47b8ac27041ca35e2110
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08507681B2
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