Butanal → Methyl 4-(1-hydroxybutyl)-3-methylbenzoate

HRID 1892669

반응식

I[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[CH3:12].[CH:13](=[O:17])[CH2:14][CH2:15][CH3:16]>>[OH:17][CH:13]([C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[CH3:12])[CH2:14][CH2:15][CH3:16]

참가 물질

반응물 2

HCID 261Butanal

HCID 231757Methyl 4-Iodo-3-methylbenzoate

생성물 1

HCID 68178586Methyl 4-(1-hydroxybutyl)-3-methylbenzoate

실험 절차

The title compound was prepared by a method analogous to that described for Intermediate (16), using methyl 4-iodo-3-methylbenzoate and butyraldehyde. 1H NMR (400 MHz, CDCl3, δ): 7.87 (d, J=8.4 Hz, 1H), 7.81 (s, 1H), 7.56 (d, J=8.4 Hz, 1H), 4.98 (q, J=4.4 Hz, 1H), 3.90 (s, 3H), 2.37 (s, 3H), 1.63-1.72 (m, 2H), 1.50-1.54 (m, 1H), 1.39-1.43 (m, 1H), 0.98 (t, J=7.6 Hz, 3H).

출처 및 근거

ORD 기록: ord-3436834444e94560b9f5c9033267487b
출처 데이터셋: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08507533B2

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