4-{4-[2-(4-Pentyl-cyclohexyl)-ethenyl]-phenyl}cyclohexane carboxylic acid methyl ester → 4-{4-[2-(4-Pentyl-cyclohexyl)-ethyl]-phenyl}-cyclohexane carboxylic acid methyl ester

HRID 1893077노트

반응식

HRID 1893077 반응식
[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:16]=[CH:15][C:14]([CH:17]=[CH:18][CH:19]3[CH2:24][CH2:23][CH:22]([CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:21][CH2:20]3)=[CH:13][CH:12]=2)[CH2:7][CH2:6]1)=[O:4]>C1(C)C=CC=CC=1.C(O)C.[Pd]>[CH3:1][O:2][C:3]([CH:5]1[CH2:6][CH2:7][CH:8]([C:11]2[CH:12]=[CH:13][C:14]([CH2:17][CH2:18][CH:19]3[CH2:20][CH2:21][CH:22]([CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:23][CH2:24]3)=[CH:15][CH:16]=2)[CH2:9][CH2:10]1)=[O:4]

참가 물질

5

반응물 1

HCID 584532174-{4-[2-(4-Pentyl-cyclohexyl)-ethenyl]-phenyl}cyclohexane carboxylic acid methyl ester

생성물 1

HCID 584532084-{4-[2-(4-Pentyl-cyclohexyl)-ethyl]-phenyl}-cyclohexane carboxylic acid methyl ester수율 88%

시약·촉매·용매 3

HCID 23938Palladium촉매2회HCID 702Ethanol용매HCID 1140Toluene용매

실험 절차

6.9 g (17.4 mmol) of 4-{4-[2-(4-pentyl-cyclohexyl)-vinyl]-phenyl}cyclohexane carboxylic acid methyl ester produced in Example 6-1 was dissolved in a mixture of toluene and ethanol (1:1 by volume %). 0.4 g of Pd/C was added to 200 mL of the resultant solution and reacted in hydrogenation reactor for 12 hours. After reaction, Pd/C was removed by filtration, concentrated under reduced pressure and recrystallized from chloroform and ethanol to obtain 6.1 g (88%) of 4-{4-[2-(4-pentyl-cyclohexyl)-ethyl]-phenyl}-cyclohexane carboxylic acid methyl ester.

후처리

  1. customreacted in hydrogenation reactor for 12 hours
  2. customwas removed by filtration
  3. concentrationconcentrated under reduced pressure
  4. customrecrystallized from chloroform and ethanol

출처 및 근거

ORD 기록
ord-0091151366e44444b24dc1fd0e3e3bcd
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08512598B2

반응 노트

불러오는 중…