HCID 59493249, 화합물 → HCID 42613828, 화합물

HRID 1893167노트

반응식

HRID 1893167 반응식
C([O:3][C:4](=[O:37])[CH:5]([O:34][CH2:35][CH3:36])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[C:18]([N:20]3[CH2:25][CH2:24][N:23]([CH2:26][C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[CH2:22][CH2:21]3)[N:17]=[C:16]([NH2:33])[N:15]=2)=[CH:9][CH:8]=1)C>O1CCCC1.O.[K]>[NH2:33][C:16]1[N:15]=[C:14]([O:13][C:10]2[CH:11]=[CH:12][C:7]([CH2:6][CH:5]([O:34][CH2:35][CH3:36])[C:4]([OH:37])=[O:3])=[CH:8][CH:9]=2)[CH:19]=[C:18]([N:20]2[CH2:25][CH2:24][N:23]([CH2:26][C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH2:22][CH2:21]2)[N:17]=1

참가 물질

4

반응물 1

HCID 59493249HCID 59493249, 화합물

생성물 1

HCID 42613828HCID 42613828, 화합물

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 5347118072414-64-3용매

실험 절차

rac-3-{4-[2-Amino-6-(4-benzyl-piperazin-1-yl)-pyrimidin-4-yloxy]-phenyl}-2-ethoxy-propionic acid ethyl ester was dissolved in tetrahydrofuran (THF)/alcohol solvent in the presence of an excess of aqueous potassium hydrate, the reaction is allowed to proceed for about 20 h. After most of the solve was removed in vacuo, the aqueous solution was acidified to pH 6, the white product was precipitated, then filtered through celite, rac-3-{4-[2-Amino-6-(4-benzyl-piperazin-1-yl)-pyrimidin-4-yloxy]-phenyl}-2-ethoxy-propionic acid (95%) was collected.

후처리

  1. customAfter most of the solve was removed in vacuo
  2. customthe white product was precipitated
  3. filtrationfiltered through celite, rac-3-{4-[2-Amino-6-(4-benzyl-piperazin-1-yl)-pyrimidin-4-yloxy]-phenyl}-2-ethoxy-propionic acid (95%)
  4. customwas collected

출처 및 근거

ORD 기록
ord-119a4c87c1d64bc2906164ecbafa9d9d
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08513233B2

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