4-Benzo[1,3]dioxol-5-yl-4-hydroxycyclohexanone → N-{[1-(4-Benzo[1,3]dioxol-5-yl-4-hydroxy-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide
반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3([OH:17])[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]3)=[CH:9][C:4]=2[O:3][CH2:2]1.[NH:18]1[CH2:21][CH:20]([NH:22][C:23]([CH2:25][NH:26][C:27](=[O:38])[C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[CH:29]=2)=[O:24])[CH2:19]1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3([OH:17])[CH2:15][CH2:14][CH:13]([N:18]4[CH2:21][CH:20]([NH:22][C:23]([CH2:25][NH:26][C:27](=[O:38])[C:28]5[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:35])[F:36])[CH:29]=5)=[O:24])[CH2:19]4)[CH2:12][CH2:11]3)=[CH:9][C:4]=2[O:3][CH2:2]1참가 물질
3
실험 절차
The title compound was prepared as a white solid by reductive amination of 4-benzo[1,3]dioxol-5-yl-4-hydroxy-cyclohexanone (as prepared in Example 1, Step B) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in step B of Example 4) using the procedure described in Step C of Example 4.
출처 및 근거
- ORD 기록
- ord-f55fb4bdaecd4867948b992615892baf