Chlorosuccinimide → 2,3-Dichloro-7-[(2,4-dichlorophenyl)carbonyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

HRID 1893424노트

반응식

HRID 1893424 반응식
[Cl:1][C:2]1[N:6]2[CH2:7][CH2:8][N:9]([C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])=[O:12])[CH2:10][C:5]2=[N:4][CH:3]=1.C1C(=O)N([Cl:28])C(=O)C1>CN(C)C=O>[Cl:28][C:3]1[N:4]=[C:5]2[CH2:10][N:9]([C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])=[O:12])[CH2:8][CH2:7][N:6]2[C:2]=1[Cl:1]

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 497855443-Chloro-7-[(2,4-dichlorophenyl)carbonyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

생성물 1

HCID 497853692,3-Dichloro-7-[(2,4-dichlorophenyl)carbonyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

3-Chloro-7-[(2,4-dichlorophenyl)carbonyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (E44) (300 mg, 0.907 mmol) and NCS (133 mg, 0.998 mmol) were stirred at RT for 16 h in N,N-dimethylformamide (DMF) (2 mL). Solvents were removed in vacuo and the residue was purified by MDAP to afford desired product in 218 mg.

후처리

  1. customSolvents were removed in vacuo
  2. customthe residue was purified by MDAP

출처 및 근거

ORD 기록
ord-618783c4af4f40a796e4693773344cd3
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08513248B2

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