2-Nitroso-1,2,3,4-tetrahydroisoquinoline → N-methyl-3,4-dihydro-1H-isoquinolin-2-amine

HRID 1893518노트

반응식

HRID 1893518 반응식
[CH2:1]=[N:2][N:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4]1.N(N1CCC2C(=CC=CC=2)C1)=O>>[CH3:1][NH:2][N:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4]1

참가 물질

3

반응물 2

HCID 122768662-Nitroso-1,2,3,4-tetrahydroisoquinolineHCID 66881110HCID 66881110, 화합물

생성물 1

HCID 409505N-methyl-3,4-dihydro-1H-isoquinolin-2-amine수율 95%

실험 절차

Using N-methylene-3,4-dihydroisoquinolin-2 (1H)-amine and the compound (3.00 g, 18.5 mmol) obtained in step A, and according to the method of Reference Example 37, step B, the title compound (2.86 g, yield 95%) was obtained as a pale-yellow oil.

출처 및 근거

ORD 기록
ord-6058bc7855034e9f8089b71b0a4a8537
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08513235B2

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