Hydrogen chloride-ethyl acetate → HCID 66881276, 화합물
반응식
[Br:1][C:2]1[CH:3]=[C:4]([NH:11]C(=O)OC(C)(C)C)[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1.[ClH:19].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:19].[Br:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1참가 물질
4
실험 절차
The compound (6.27 g, 20.0 mmol) obtained in step A was dissolved in ethyl acetate, 4N hydrochloric acid-ethyl acetate solution (25 ml, 100 mmol) was added at room temperature with stirring, and the mixture was stirred at the same temperature overnight. The precipitated solid was filtered, washed with ethyl acetate, and dried under reduced pressure to give the title compound (4.65 g, yield 93%) as a colorless solid.
후처리
- stirringthe mixture was stirred at the same temperature overnight
- filtrationThe precipitated solid was filtered
- washwashed with ethyl acetate
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-bd3bedd2808c48d599b9de5c7b2ec225
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08513235B2
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