3-Chloroisoquinoline → 3-Ethoxyisoquinoline

HRID 1893630

반응식

HRID 1893630 반응식
Cl[C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[O-:12][CH2:13][CH3:14].[K+]>>[CH2:13]([O:12][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:14]

참가 물질

3

반응물 2

HCID 6409683-ChloroisoquinolineHCID 23670592Potassium ethoxide

생성물 1

HCID 6409663-Ethoxyisoquinoline수율 48.1%

반응 조건

온도
150 °C

실험 절차

3-Chloroisoquinoline (3.0, 18 mmol) was dissolved in potassium ethoxide (24% in EtOH, 10.6 mL, 27 mmol) and heated to 150° C. in a sealed tube for 24 h. After cooling, the solvent was removed in vacuo and the residue treated with 1M HCl until the solution reaches a pH 3. Saturated NaHCO3 solution then added slowly to return the solution to pH 8 followed by extraction with CHCl3. The combined organics were washed with brine, dried over anhydrous MgSO4. The residue obtained from concentration in vacuo was purified by column chromatography on SiO2 (0-15% EtOAc, hex) to afford 1.5 g (48%) of 3-ethoxyisoquinoline. LCMS found 174.11 [M+H]+.

후처리

  1. temperatureAfter cooling
  2. customthe solvent was removed in vacuo
  3. additionthe residue treated with 1M HCl until the solution
  4. additionSaturated NaHCO3 solution then added slowly
  5. extractionfollowed by extraction with CHCl3
  6. washThe combined organics were washed with brine
  7. dry with materialdried over anhydrous MgSO4
  8. customThe residue obtained from concentration in vacuo
  9. customwas purified by column chromatography on SiO2 (0-15% EtOAc, hex)

출처 및 근거

ORD 기록
ord-95f243b864494b37b10402ec18ea33dc
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08513186B2

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