4-(2-tert-butyl-5-nitro-1H-pyrrole-4-carbonyl)-3,3-dimethylpiperazin-2-one → 4-(2-amino-5-tert-butyl-1H-pyrrole-3-carbonyl)-3,3-dimethylpiperazin-2-one

HRID 18937

반응식

HRID 18937 반응식
[C:1]([C:5]1[NH:6][C:7]([N+:21]([O-])=O)=[C:8]([C:10]([N:12]2[CH2:17][CH2:16][NH:15][C:14](=[O:18])[C:13]2([CH3:20])[CH3:19])=[O:11])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[NH2:21][C:7]1[NH:6][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:9][C:8]=1[C:10]([N:12]1[CH2:17][CH2:16][NH:15][C:14](=[O:18])[C:13]1([CH3:19])[CH3:20])=[O:11]

참가 물질

4

반응물 1

HCID 586793674-(2-tert-butyl-5-nitro-1H-pyrrole-4-carbonyl)-3,3-dimethylpiperazin-2-one

생성물 1

HCID 586792354-(2-amino-5-tert-butyl-1H-pyrrole-3-carbonyl)-3,3-dimethylpiperazin-2-one

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To 4-(2-tert-butyl-5-nitro-1H-pyrrole-4-carbonyl)-3,3-dimethylpiperazin-2-one (120 mg) in methanol (10 mL) was added Pd catalyst (10% on carbon, 60 mg) and the resulting reaction mixture was stirred under H2 at 60 psi for overnight. After the solids were removed by filtration over Celite, the solvent was removed in vacuo to afford 4-(2-amino-5-tert-butyl-1H-pyrrole-3-carbonyl)-3,3-dimethylpiperazin-2-one 7 as a yellow film (100 mg, 92%).

후처리

  1. customthe resulting reaction mixture
  2. customAfter the solids were removed by filtration over Celite
  3. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-51c3ecd5f60144d39cf31500a3d542e9
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741479B2

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