Boron tribromide → N,N-Diethyl-3-hydroxybenzamide
반응식
[CH2:1]([N:3]([CH2:14][CH3:15])[C:4](=[O:13])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11]C)[CH:6]=1)[CH3:2].B(Br)(Br)Br>C(Cl)Cl>[CH2:14]([N:3]([CH2:1][CH3:2])[C:4](=[O:13])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([OH:11])[CH:6]=1)[CH3:15]참가 물질
4
실험 절차
To a solution of Compound 15a (0.68 g; 3.28 mmol) in CH2Cl2 (50 mL) was added BBr3 (1.0M in CH2Cl2) (16 mL; 16 mmol) dropwise at 0° C. The reaction was stirred at room temperature for 1 h. The mixture was quenched with saturated aqueous NaHCO3. The organic layer was dried over MgSO4 and concentrated to afford Compound 15b. The crude product was used in the next reaction without further purification. MS m/z 194.2 (M+H)+.
후처리
- customThe mixture was quenched with saturated aqueous NaHCO3
- dry with materialThe organic layer was dried over MgSO4
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-e2d39c1d830c4dd68885677bb4c0d4b3
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08513271B2
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