N,N-dimethyl-2-(piperazin-1-yl)acetamide → 2-{4-[2-(2-tert-Butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-dimethyl-acetamide

참여 물질

역할	이름	HCID	투입량
반응물	N,N-dimethyl-2-(piperazin-1-yl)acetamide	HCID 2758642	—
반응물	rac-(4S,5R)-2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 76588520	—
생성물	2-{4-[2-(2-tert-Butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-dimethyl-acetamide	HCID 25262573	—

반응 단계

In a manner analogous to the method described in example 3, rac-(4S*,5R*)-2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride was reacted with N,N-dimethyl-2-piperazin-1-yl-acetamide (Oakwood Products) to give the title compound as a racemic mixture. HR-MS (ES, m/z) calculated for C36H46N7O3Cl2 [(M+H)+] 694.3034, observed 694.3035.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08513239B2
출처 데이터셋	uspto-grants-2013_08
ORD ID	ord-80757d16f1b749f0a28ecfc67720eb3c
출처 메모	uspto-grants-2013_08