gamma-Hydroxypropyl ethyl sulfide → [(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-ethanesulfonyl-propyl)-piperazin-1-yl]-methanone

참여 물질

역할	이름	HCID	투입량
반응물	gamma-Hydroxypropyl ethyl sulfide	HCID 87762	—
반응물	1-(3-(Methylsulfonyl)propyl)piperazine dihydrochloride	HCID 49853479	—
반응물	(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 57669958	—
반응물	1-(3-Ethanesulfonyl-propyl)-piperazine dihydrochloride	HCID 67071500	—
생성물	[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-ethanesulfonyl-propyl)-piperazin-1-yl]-methanone	HCID 25261187	—

반응 단계

In a manner analogous to the method described in examples 8, (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride (example 51) was coupled with 1-(3-ethanesulfonyl-propyl)-piperazine dihydrochloride (prepared from 3-ethylsulfanyl-propan-1-ol in an analogous manner as the method described for 1-(3-methanesulfonyl-propyl)-piperazine dihydrochloride, Ding, Q. et al. WO2007063013) to give the title compound. HR-MS (ES, m/z) calculated for C38H50Cl2N5O4S [(M+H)+] 742.2955, observed 742.2952.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08513239B2
출처 데이터셋	uspto-grants-2013_08
ORD ID	ord-17de0284be6642bd9ad711b95a425ff3
출처 메모	uspto-grants-2013_08