1-(3-Methoxypropyl)piperazine → [(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methoxy-propyl)-piperazin-1-yl]-methanone

참여 물질

역할	이름	HCID	투입량
반응물	1-(3-Methoxypropyl)piperazine	HCID 1822536	—
반응물	(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 57669958	—
생성물	[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methoxy-propyl)-piperazin-1-yl]-methanone	HCID 57670088	—

반응 단계

In a manner analogous to the method described in examples 8, (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride (example 51) was coupled with 1-(3-methoxy-propyl)-piperazine (Oakwood) to give the title compound. HR-MS (ES, m/z) calculated for C37H48Cl2N5O3 [(M+H)+] 680.3129, observed 680.3133.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08513239B2
출처 데이터셋	uspto-grants-2013_08
ORD ID	ord-c4511e33ab7e40ed98c9d5d68bb933fb
출처 메모	uspto-grants-2013_08