(R)-3-Methoxypyrrolidine → 2-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-1-((R)-3-methoxy-pyrrolidin-1-yl)-ethanone

참여 물질

역할	이름	HCID	투입량
반응물	(R)-3-Methoxypyrrolidine	HCID 15086791	—
반응물	{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetic acid	HCID 25262899	—
생성물	2-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-1-((R)-3-methoxy-pyrrolidin-1-yl)-ethanone	HCID 57670054	—

반응 단계

In a manner analogous to the method described in example 99, {4-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetic acid was coupled with (R)-3-methoxy-pyrrolidine (Aldrich) to give the title compound. HR-MS (ES, m/z) calculated for C40H51Cl2N6O4 [(M+H)+] 749.3344, observed 749.3337.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08513239B2
출처 데이터셋	uspto-grants-2013_08
ORD ID	ord-b7bf6a386ef9431fab80a74bdd021170
출처 메모	uspto-grants-2013_08