(Z)-2-Hydroxydoxepin → (E)-2-Hydroxy Doxepin

HRID 1894781

반응식

HRID 1894781 반응식
[OH:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][CH2:7][C:8]3[CH:20]=[CH:19][CH:18]=[CH:17][C:9]=3/[C:10](=[CH:11]/[CH2:12][CH2:13][N:14]([CH3:16])[CH3:15])/[C:4]=2[CH:3]=1>Cl.CO>[OH:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][CH2:7][C:8]3[CH:20]=[CH:19][CH:18]=[CH:17][C:9]=3/[C:10](=[CH:11]\[CH2:12][CH2:13][N:14]([CH3:16])[CH3:15])/[C:4]=2[CH:3]=1

참가 물질

4

반응물 1

HCID 67319009(Z)-2-Hydroxydoxepin

생성물 1

HCID 59023617(E)-2-Hydroxy Doxepin

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 887Methanol용매

반응 조건

온도
140 °C

실험 절차

A mixture of (Z)-2-Hydroxy-11-(3-dimethylaminopropylidene)-6,11-dihydrodibenzo[b,e]oxepin (2.5 mg, 8.5×10−6 mol) was dissolved in a mixture of hydrochloric acid (1 mL) and methanol (9 mL) and heated at 140° C. (oil bath) for 4 hr. The product was isolated by means of HPLC and evaporation of solvents.

후처리

  1. customThe product was isolated by means of HPLC and evaporation of solvents

출처 및 근거

ORD 기록
ord-d7316b5332224b23afe943ea57d90c92
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08513299B2

연결된 노트

불러오는 중…