참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Aniline | HCID 6115 | — |
| 반응물 | Ammonium Hydroxide | HCID 14923 | — |
| 반응물 | Sodium Dithionite | HCID 24489 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 6-Methyl-4'-nitro-N-[3-(trifluoromethyl)phenyl]biphenyl-3-carboxamide | HCID 69042860 | — |
| 생성물 | 4'-Amino-6-methyl-N-[3-(trifluoromethyl)phenyl]biphenyl-3-carboxamide | HCID 69043109 | — |
반응 단계
6-Methyl-4′-nitro-N-[3-(trifluoromethyl)phenyl]biphenyl-3-carboxamide was dissolved in 1,4-dioxane (10.00 mL, 0.1281 mol) and water (5.00 mL, 0.278 mol), and ammonium hydroxide (0.18 mL, 0.0045 mol) was added. To the reaction was added sodium dithionite (1.10 g, 0.00632 mol) and this mixture was stirred at 25° C. for 2 hours at which time HPLC analysis showed aniline formation. The reaction was extracted with ethyl acetate and the organic extracts were washed with water, saturated NaCl, dried (MgSO4) and concentrated in vacuo. MS (EI) m/z=371 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08513270B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_08 |
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| ORD ID | ord-1fcedce4e3c04c45a9efd8a4a77f8d19 |
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| 출처 메모 | uspto-grants-2013_08 |
|---|
