Triethylamine → N-(5-iodo-6-methylpyridin-3-yl)-3-(trifluoromethyl)benzamide

HRID 1894905노트

반응식

HRID 1894905 반응식
[I:1][C:2]1[CH:3]=[C:4]([NH2:9])[CH:5]=[N:6][C:7]=1[CH3:8].C(N(CC)CC)C.[F:17][C:18]([F:29])([F:28])[C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][CH:27]=1)[C:22](Cl)=[O:23]>C(Cl)Cl>[I:1][C:2]1[CH:3]=[C:4]([NH:9][C:22](=[O:23])[C:21]2[CH:25]=[CH:26][CH:27]=[C:19]([C:18]([F:17])([F:28])[F:29])[CH:20]=2)[CH:5]=[N:6][C:7]=1[CH3:8]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 752573-(Trifluoromethyl)benzoyl chlorideHCID 591982915-Iodo-6-methylpyridin-3-amine

생성물 1

HCID 69042846N-(5-iodo-6-methylpyridin-3-yl)-3-(trifluoromethyl)benzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

To a solution of 5-iodo-6-methylpyridin-3-amine (125 mg, 0.534 mmol) in methylene chloride (1 mL) was added triethylamine (0.087 mL, 0.627 mmol) and cooled at 0° C. Into the reaction was added 3-(trifluoromethyl)benzoyl chloride (0.0812 mL, 0.538 mmol) dropwise and stirred at 0° C. for 45 minutes and at 25° C. for 16 hours. The reaction was extracted with EtOAc and the organic extracts were washed with water saturated Na2CO3, saturated NaCl, dried (MgSO4) and stripped in vacuo. The product was used in the next reaction without purification.

후처리

  1. extractionThe reaction was extracted with EtOAc
  2. washthe organic extracts were washed with water saturated Na2CO3, saturated NaCl
  3. dry with materialdried (MgSO4)
  4. customThe product was used in the next reaction without purification

출처 및 근거

ORD 기록
ord-fdd556997cbd490fa4e181c61ae4a092
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08513270B2

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