Diethyl 2,2-dihexylmalonate → 2,2-Dihexylpropane-1,3-diol

HRID 1894912노트

반응식

HRID 1894912 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].C([O:9][C:10](=O)[C:11]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[C:12](OCC)=[O:13])C>C1COCC1>[CH2:23]([C:11]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([CH2:10][OH:9])[CH2:12][OH:13])[CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

참가 물질

4

반응물 2

HCID 599758Diethyl 2,2-dihexylmalonateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 227192912,2-Dihexylpropane-1,3-diol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A suspension of lithium aluminum hydride (LAH) (2 g, 52.6 mmol) in dry THF (20 mL) was stirred at room temperature, and a THF solution of substituted malonic acid diethyl ester (26.3 mmol, (5)) was added dropwise. The reaction was allowed to reflux for 3 h and was quenched by the addition of cold water. The compound was extracted in ethyl acetate. The organic layer was washed with water, dried over Na2SO4, and evaporated to produce the product (6) as either a sticky liquid or a low-melting solid.

후처리

  1. temperatureto reflux for 3 h
  2. customwas quenched by the addition of cold water
  3. extractionThe compound was extracted in ethyl acetate
  4. washThe organic layer was washed with water
  5. dry with materialdried over Na2SO4
  6. customevaporated

출처 및 근거

ORD 기록
ord-936311ea707f473badfa981acc5f2672
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08513377B2

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