HCID 67646998, 화합물 → 3-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidine

HRID 1895노트

반응식

HRID 1895 반응식
[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][N:15](CC2C=CC=CC=2)[CH2:14]1)[CH:10]1[CH2:12][CH2:11]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>CO.[Pd]>[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][NH:15][CH2:14]1)[CH:10]1[CH2:11][CH2:12]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

참가 물질

4

반응물 1

HCID 67646998HCID 67646998, 화합물

생성물 1

HCID 196914723-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidine수율 35.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A sample (548 mg) of the compound from step 470d was dissolved in methanol, 140 mg of 10% Pd/C was added, and the mixture was hydrogenated at 4 atm H2 for 42 hours at room temperature. The solution was filtered, and the solvent was removed to give 140 mg of the title compound.

후처리

  1. filtrationThe solution was filtered
  2. customthe solvent was removed

출처 및 근거

ORD 기록
ord-599ef965de604788a8f4493886ac4c46
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05726182

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