참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Hydroxy-2(1H)-pyridinone | HCID 54696004 | — |
| 반응물 | Benzyl 4-((methanesulfonyl)oxy)piperidine-1-carboxylate | HCID 58303455 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Benzyl 4-(2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate | HCID 67366192 | 37.2% |
반응 단계
A stirring suspension of benzyl 4-(methylsulfonyloxy)piperidine-1-carboxylate (1.97 g, 6.30 mmol), 4-hydroxypyridin-2(1H)-one (0.50 g, 4.5 mmol, Aldrich), potassium carbonate (1.43 g, 10.6 mmol, EMD) and DMF (25 mL) was heated at 140° C. for 2.5 h and then cooled to room temperature. The resulting mixture was diluted with H2O and extracted with EtOAc (2×). The organic layers were combined and washed with brine, dried over Na2SO4 and concentrated in vacuo to a light yellow oil. The oil was purified by flash chromatography (SiO2, 0 to 10% MeOH in CH2Cl2) to yield 550 mg of desired product as a white solid. MS (ESI) 329 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08513424B2 |
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| 출처 데이터셋 | uspto-grants-2013_08 |
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| ORD ID | ord-43864b9d5a2641cd80559a7a08a6fe77 |
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| 출처 메모 | uspto-grants-2013_08 |
|---|
