Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphorus oxychloride → 1-Chloro-6-methoxy-3-methylisoquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 6-Methoxy-3-methylisoquinolin-1(2H)-one | HCID 12327060 | — |
| 생성물 | 1-Chloro-6-methoxy-3-methylisoquinoline | HCID 57893095 | — |
반응 단계
Isoquinoline-1-one 43 was dissolved in POCl3 (2.5 mL) and heated at reflux for 1 h. The excess POCl3 was removed in vacuo and the residue was dissolved in CHCl3. The resulting solution was washed with 1N aq. NaOH, water and saturated ag. NaCl. Evaporation of the solvent gave crude 44 which was used directly in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08518874B2 |
| 출처 데이터셋 | uspto-grants-2013_08 |
| ORD ID | ord-834bf06d1b42452fa9412b9fc8ede38d |
| 출처 메모 | uspto-grants-2013_08 |