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Trifluoroacetic acid → Trifluoroacetic acid

HRID 1895937
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HRID 1895937 반응식
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[O:8]=[C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11](=[O:18])[N:10]1[O:19][C@H:20]1[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21]1>C(Cl)Cl>[NH:22]1[CH2:23][CH2:24][C@H:20]([O:19][N:10]2[C:11](=[O:18])[C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:9]2=[O:8])[CH2:21]1.[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 6422Trifluoroacetic acidHCID 59704735(S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

생성물 2

HCID 6422Trifluoroacetic acid수율 242.9%HCID 67118875(S)-2-(pyrrolidin-3-yloxy)isoindoline-1,3-dione

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (3.42 g, 30 mmol) was added at 0° C. to a solution of (S)-tert-butyl 3-(1,3-dioxoisoin dolin-2-yloxy)pyrrolidin-1-carboxylate (3.32 g, 10 mmol) in CH2Cl2 (25 ml), and the whole was stirred at room temperature for 17 hours. The reaction was concentrated in vacuo and the residue was triturated with diethyl ether (100 ml) to give (S)-2-(pyrrolidin-3-yloxy)isoindoline-1,3-dione) trifluoroacetic acid salt (2.77 g, 80%) as a white solid.

후처리

  1. concentrationThe reaction was concentrated in vacuo
  2. customthe residue was triturated with diethyl ether (100 ml)

출처 및 근거

ORD 기록
ord-63c34f0f09244c3287e5816e7615d725
출처 데이터셋
uspto-grants-2013_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08518934B2

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