Tert-butyl 4-[3-(5-cyanopyridin-3-yl)prop-2-ynylidene]piperidine-1-carboxylate → 5-(3-Piperidin-4-ylideneprop-1-ynyl)pyridine-2-carbonitrile

HRID 1895968노트

반응식

HRID 1895968 반응식
C[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]#[C:9][CH:10]=[C:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[N:3]=1.[C:17](C1C=C(C#CC=C2CCN(C(OC(C)(C)C)=O)CC2)C=NC=1)#[N:18]>>[NH:14]1[CH2:13][CH2:12][C:11](=[CH:10][C:9]#[C:8][C:4]2[CH:5]=[CH:6][C:7]([C:2]#[N:3])=[N:18][CH:17]=2)[CH2:16][CH2:15]1

참가 물질

3

반응물 2

HCID 25183829Tert-butyl 4-[3-(5-cyanopyridin-3-yl)prop-2-ynylidene]piperidine-1-carboxylateHCID 875504022-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

생성물 1

HCID 875497035-(3-Piperidin-4-ylideneprop-1-ynyl)pyridine-2-carbonitrile

실험 절차

The title compounds were prepared following the procedure described for the compound of Example 3 but starting respectively from the compounds of Example 45 and 46 instead of the compound of Example 2. The crudes were used in the next step without further purification.

후처리

  1. customThe crudes were used in the next step without further purification

출처 및 근거

ORD 기록
ord-77ce2b0e472a4b3587e90754b2777946
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518916B2

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