Tert-butyl 4-[1-hydroxy-3-(6-methylpyridin-2-yl)prop-2-ynyl]piperidine-1-carboxylate → 3-(6-Methyl-pyridin-2-yl)-1-piperidin-4-yl-prop-2-yn-1-ol

HRID 1895992노트

반응식

HRID 1895992 반응식
CC1C=CC=C(C#CC=C2CCNCC2)N=1.[OH:17][CH:18]([CH:28]1[CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29]1)[C:19]#[C:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH3:27])[N:22]=1>>[CH3:27][C:23]1[N:22]=[C:21]([C:20]#[C:19][CH:18]([CH:28]2[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]2)[OH:17])[CH:26]=[CH:25][CH:24]=1

참가 물질

3

반응물 2

HCID 68725592Tert-butyl 4-[1-hydroxy-3-(6-methylpyridin-2-yl)prop-2-ynyl]piperidine-1-carboxylateHCID 875504022-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

생성물 1

HCID 689774953-(6-Methyl-pyridin-2-yl)-1-piperidin-4-yl-prop-2-yn-1-ol

실험 절차

The title compound was prepared following the procedure described for the compound of Example 3, using the Compound of Example 39 instead of the Compound of Example 2. After the usual work-up procedure, the crude was used in the next step without further purification.

후처리

  1. customAfter the usual work-up procedure, the crude was used in the next step without further purification

출처 및 근거

ORD 기록
ord-4517455cfc04487fa2d27d7eb5470dec
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518916B2

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