Tert-butyl 4-[3-(3,5-difluorophenyl)prop-2-yn-1-yl]piperidine-1-carboxylate → 4-[3-(3,5-Difluorophenyl)prop-2-ynyl]piperidine

HRID 1895999노트

반응식

HRID 1895999 반응식
CC1C=CC=C(C#CC=C2CCNCC2)N=1.[F:17][C:18]1[CH:19]=[C:20]([C:25]#[C:26][CH2:27][CH:28]2[CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29]2)[CH:21]=[C:22]([F:24])[CH:23]=1>>[F:17][C:18]1[CH:19]=[C:20]([C:25]#[C:26][CH2:27][CH:28]2[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]2)[CH:21]=[C:22]([F:24])[CH:23]=1

참가 물질

3

반응물 2

HCID 68726123Tert-butyl 4-[3-(3,5-difluorophenyl)prop-2-yn-1-yl]piperidine-1-carboxylateHCID 875504022-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

생성물 1

HCID 689794914-[3-(3,5-Difluorophenyl)prop-2-ynyl]piperidine

실험 절차

The title compound was prepared following the procedure described for the Compound of Example 3, using the Compound of Example 247 instead of the Compound of Example 2. After the usual work-up procedure, the crude was used for the next step without further purification.

후처리

  1. customAfter the usual work-up procedure, the crude was used for the next step without further purification

출처 및 근거

ORD 기록
ord-76778855337f410894fdcfa7854d8862
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518916B2

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