2-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine → 2-Bromo-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

HRID 1896035노트

반응식

HRID 1896035 반응식
CC1C=CC=C(C#CC=C2CCNCC2)N=1.[Br:17][C:18]1[N:23]=[C:22]([C:24]#[C:25][CH:26]=[C:27]2[CH2:32][CH2:31][N:30](C(OC(C)(C)C)=O)[CH2:29][CH2:28]2)[CH:21]=[CH:20][CH:19]=1>>[Br:17][C:18]1[CH:19]=[CH:20][CH:21]=[C:22]([C:24]#[C:25][CH:26]=[C:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[N:23]=1

참가 물질

3

반응물 2

HCID 875504022-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridineHCID 87641844Tert-butyl 4-[3-(6-bromopyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxylate

생성물 1

HCID 876422122-Bromo-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

실험 절차

The title product was prepared following the method described for the Compound of Example 3 but using as starting material Compound 305a instead of the Compound of Example 2 and stirring at ambient temperature for 3 days. The reaction mixture was evaporated to dryness in vacuo, taking up the residue several times with chloroform to remove excess trifluoroacetic acid.

후처리

  1. customThe reaction mixture was evaporated to dryness in vacuo
  2. customto remove excess trifluoroacetic acid

출처 및 근거

ORD 기록
ord-213125f6597a4d6fa6d15b244e585472
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518916B2

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