Hydrochloride methanol → cis-1,2,3,4,4a,5,6,11b-Octahydro-7h-pyrido[3,4-d][2]benzazepin-7-one

HRID 1896141노트

반응식

HRID 1896141 반응식
[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]2[CH2:13][CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16][C@H:5]2[CH2:4][NH:3]1.Cl.CO>C(OCC)C>[CH2:13]1[C@H:6]2[C@H:5]([CH2:4][NH:3][C:2](=[O:1])[C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=32)[CH2:16][NH:15][CH2:14]1

참가 물질

4

반응물 2

HCID 21893726Hydrochloride methanolHCID 67249978Tert-butyl cis-7-oxo-1,2,4,4a,5,6,7,11b-octahydro-3h-pyrido[3,4-d][2]benzazepine-3-carboxylate

생성물 1

HCID 49763200cis-1,2,3,4,4a,5,6,11b-Octahydro-7h-pyrido[3,4-d][2]benzazepin-7-one

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a suspension of Example 180G in 400 mL of diethyl ether was added 80 mL of HCl/methanol (5/V) at 25° C. The mixture was stirred overnight. The solid formed was collected and dried to obtain the title compound as the hydrochloride salt.

후처리

  1. customThe solid formed
  2. customwas collected
  3. customdried

출처 및 근거

ORD 기록
ord-f3ca9d70d2ea425595ebc61e8fc93a30
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518933B2

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