Thiophene-3-boronic acid → 2-Phenyl-6-(thiophen-3-yl)pyrimidine-4-carboxylic acid

반응식

Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]([C:14]([OH:16])=[O:15])[CH:3]=1.[S:17]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18]1>>[C:8]1([C:6]2[N:5]=[C:4]([C:14]([OH:16])=[O:15])[CH:3]=[C:2]([C:19]3[CH:20]=[CH:21][S:17][CH:18]=3)[N:7]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

반응물 2

HCID 581760Thiophene-3-boronic acid

HCID 574316986-Chloro-2-phenylpyrimidine-4-carboxylic acid

생성물 1

HCID 684442932-Phenyl-6-(thiophen-3-yl)pyrimidine-4-carboxylic acid

실험 절차

This compound was prepared using a method analogous to that of Example 32, step 32.1, 6-chloro-2-phenyl-pyrimidine-4-carboxylic acid replacing intermediate 14.1 and thiophene-3-boronic acid replacing phenylboronic acid. The crude was however crystallized (EtOH/H20 2/1). LC-MS (A): tR=1.03 min; [M+H]+: 283.03.

후처리

customThis compound was prepared
customThe crude was however crystallized (EtOH/H20 2/1)

출처 및 근거

ORD 기록: ord-b2881ada9da5452398a133824c769373
출처 데이터셋: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08518912B2

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