HCID 22459185, 화합물 → HCID 86623474, 화합물
반응식
[C:1](OC(=NC1CCCCC1)NC1CCCCC1)([CH3:4])([CH3:3])[CH3:2].[Cl:21][C:22]1[CH:27]=[C:26]([CH2:28][C:29]([OH:31])=[O:30])[CH:25]=[CH:24][N:23]=1>C(Cl)Cl>[Cl:21][C:22]1[CH:27]=[C:26]([CH2:28][C:29]([O:31][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:30])[CH:25]=[CH:24][N:23]=1참가 물질
4
실험 절차
Compound 2-tert-butyl-1,3-dicyclohexylisourea (650 mg, 2.30 mmol) was added to a solution of 2-(2-chloropyridin-4-yl)acetic acid (200 mg, 1.16 mmol) in DCM (5 ml) at room temperature. The reaction mixture was stirred for 24 h, filtered, washed with DCM (5 ml) and saturated sodium bicarbonate solution (10 ml). The solvent was evaporated in vacuum to afford 200 mg (77%) of tert-butyl 2-(2-chloropyridin-4-yl)acetate as a colorless liquid.
후처리
- filtrationfiltered
- washwashed with DCM (5 ml) and saturated sodium bicarbonate solution (10 ml)
- customThe solvent was evaporated in vacuum
출처 및 근거
- ORD 기록
- ord-9825045517764e7bae31d01ad8f7a436
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08518948B2
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