Ammonia → 1-(Aminomethyl)-4-propylpyrrolidin-2-one

HRID 1896380노트

반응식

HRID 1896380 반응식
Cl[CH2:2][N:3]1[CH2:7][CH:6]([CH2:8][CH2:9][CH3:10])[CH2:5][C:4]1=[O:11].[NH3:12]>C1(C)C=CC=CC=1>[NH2:12][CH2:2][N:3]1[CH2:7][CH:6]([CH2:8][CH2:9][CH3:10])[CH2:5][C:4]1=[O:11]

참가 물질

4

반응물 2

HCID 222Ammonia2회HCID 536292161-(Chloromethyl)-4-propylpyrrolidin-2-one

생성물 1

HCID 536292181-(Aminomethyl)-4-propylpyrrolidin-2-one

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 1-(chloromethyl)-4-propylpyrrolidin-2-one x63 (41.34 g, 0.235 mol) in toluene (350 ml) is added dropwise at −78° C. to liquid ammonia (300 ml). At the end of the addition, the temperature is raised slowly to room temperature, and ammonia of the crude mixture is allowed to distill at room temperature overnight. Filtration of the reaction mixture and subsequent evaporation lead to 55 g of the crude 1-(aminomethyl)-4-propylpyrrolidin-2-one x76 which is used without further purification.

후처리

  1. additionAt the end of the addition
  2. distillationto distill at room temperature overnight
  3. filtrationFiltration of the reaction mixture and subsequent evaporation lead to 55 g of the crude 1-(aminomethyl)-4-propylpyrrolidin-2-one x76 which
  4. customis used without further purification

출처 및 근거

ORD 기록
ord-074e5cebe0054f61a821410da7743c6c
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518943B2

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