Sodium Methoxide → HCID 57743037, 화합물

HRID 1896429노트

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HRID 1896429 반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[CH:9][C:10]([CH2:11][N:12]3[CH2:16][CH:15]([CH2:17][CH2:18][CH3:19])[CH2:14][C:13]3=[O:20])=[C:4]2[N:3]=1.[CH3:21][O-:22].[Na+]>CO>[CH3:21][O:22][C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[CH:9][C:10]([CH2:11][N:12]3[CH2:16][CH:15]([CH2:17][CH2:18][CH3:19])[CH2:14][C:13]3=[O:20])=[C:4]2[N:3]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 15979675HCID 15979675, 화합물

생성물 1

HCID 57743037HCID 57743037, 화합물수율 53.7%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
80 °C

실험 절차

To a solution of 1-[(5-chloropyrazolo[1,5-a]pyrimidin-3-yl)methyl]-4-propylpyrrolidin-2-one 205 (0.575 mmol, 1 eq, 0.22 g) in MeOH (10 ml) is added sodium methoxide (5.75 mmol, 10 eq, 0.4 g). The mixture is heated at 80° C. for 2 hours. The solvent is removed under reduce pressure, water is added and the resulting mixture is extracted with CH2Cl2. The organic phases are combined, and dried over MgSO4. Volatiles are removed under reduced pressure to afford 89 mg of 1-[(5-methoxypyrazolo[1,5-a]pyrimidin-3-yl)methyl]-4-propylpyrrolidin-2-one 208.

후처리

  1. customThe solvent is removed
  2. additionis added
  3. extractionthe resulting mixture is extracted with CH2Cl2
  4. dry with materialdried over MgSO4
  5. customVolatiles are removed under reduced pressure

출처 및 근거

ORD 기록
ord-698631f8ba2d401fb308c9b1a1ccb947
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518943B2

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