Water → 4-(Hydroxymethyl)pyridine-2-carboxamide

HRID 1896676노트

반응식

HRID 1896676 반응식
C[Si](Cl)(C)C.[C:6]([C:8]1[CH:13]=[C:12]([CH2:14][OH:15])[CH:11]=[CH:10][N:9]=1)#[N:7].O.C(=O)([O-])[O-:18].[Na+].[Na+]>C(O)C>[C:6]([C:8]1[CH:13]=[C:12]([CH2:14][OH:15])[CH:11]=[CH:10][N:9]=1)(=[O:18])[NH2:7]

참가 물질

6

반응물 4

HCID 962WaterHCID 6397ChlorotrimethylsilaneHCID 10340Sodium CarbonateHCID 107253914-(Hydroxymethyl)pyridine-2-carbonitrile2회

생성물 1

HCID 230938024-(Hydroxymethyl)pyridine-2-carboxamide

시약·촉매·용매 1

HCID 702Ethanol용매2회

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온도
50 °C

실험 절차

Trimethylsilyl chloride (27 mL) and a suspension of 2-cyanopyridine-4-methanol (1.6 g, 11 mmol, Reference compound 11-1) in ethanol (20 mL) were added to ethanol (14 mL) at room temperature under a nitrogen atmosphere, and then the mixture was stirred at 50° C. for 5.5 hours. The mixture was allowed to stand, and water (27 mL) and sodium carbonate (2.3 g, 22 mmol) were added thereto. The solvent was evaporated under reduced pressure, ethanol (100 mL) was added thereto, and the resulting insoluble matter was filtered out. The filtrate was evaporated under reduced pressure, then the resulting residue was dried at 50° C. under reduced pressure to the title reference compound including inorganic salt.

후처리

  1. customThe solvent was evaporated under reduced pressure, ethanol (100 mL)
  2. additionwas added
  3. filtrationthe resulting insoluble matter was filtered out
  4. customThe filtrate was evaporated under reduced pressure
  5. customthe resulting residue was dried at 50° C. under reduced pressure to the title reference compound

출처 및 근거

ORD 기록
ord-6a566a1cbfcb4b14b46c0e50c7097f3e
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518973B2

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