Water → 3-[6-(2-Fluorophenyl)pyridin-3-yl]propan-1-ol

HRID 1896692노트

반응식

HRID 1896692 반응식
C([O:3][C:4](=O)[CH2:5][CH2:6][C:7]1[CH:8]=[N:9][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[F:19])=[CH:11][CH:12]=1)C.[BH4-].[Li+].O>C1COCC1>[F:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[C:10]1[N:9]=[CH:8][C:7]([CH2:6][CH2:5][CH2:4][OH:3])=[CH:12][CH:11]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 4148881Lithium borohydrideHCID 68537058Ethyl 3-[6-(2-fluorophenyl)pyridin-3-yl]propanoate

생성물 1

HCID 691058943-[6-(2-Fluorophenyl)pyridin-3-yl]propan-1-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Under argon, 400 mg (1.46 mmol) of 3-(6-(2-fluorophenyl)pyridin-3-yl)propionic acid ethyl ester and 63.8 mg (2.93 mmol) of lithium borohydride were stirred in 20 ml of THF at 40° C. for 3 h. After cooling, the mixture was cautiously hydrolyzed with water, the precipitate was filtered off with suction, and water and methylene chloride were added to the filtrate. The organic phase was separated, washed with water and concentrated. Yield: 241 mg (71%).

후처리

  1. temperatureAfter cooling
  2. filtrationthe precipitate was filtered off with suction, and water and methylene chloride
  3. additionwere added to the filtrate
  4. customThe organic phase was separated
  5. washwashed with water
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-46c3041dae0141aaa168b5230838e062
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518976B2

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