2-Piperidone → 1-(3-(6-(2-Fluorophenyl)pyridin-3-yl)propyl)piperidin-2-one

반응식

Br[CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])=[N:9][CH:10]=1.[NH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][C:19]1=[O:24]>>[F:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[C:8]1[N:9]=[CH:10][C:5]([CH2:4][CH2:3][CH2:2][N:18]2[CH2:23][CH2:22][CH2:21][CH2:20][C:19]2=[O:24])=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 126652-Piperidone

HCID 691059795-(3-Bromopropyl)-2-(2-fluorophenyl)pyridine

생성물 1

HCID 160366521-(3-(6-(2-Fluorophenyl)pyridin-3-yl)propyl)piperidin-2-one

실험 절차

50 mg (0.17 mmol) of 5-(3-bromopropyl)-2-(2-fluorophenyl)pyridine were reacted with 18.5 mg (0.18 mmol) of piperidin-2-one analogously to example 1d). Yield: 16 mg (31%).

출처 및 근거

ORD 기록: ord-df95b7949afa463d87910924e2cebe44
출처 데이터셋: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08518976B2

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