Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanesulfonyl chloride → 3-(R)-(1-BOC-2-(S)-pyrrolidinyl)-4-nitrobutanyl methylsulfonyl ether
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | 3-(R)-(1-BOC-2-(S)-pyrrolidinyl)-4-nitrobutanol | HCID 22869531 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(R)-(1-BOC-2-(S)-pyrrolidinyl)-4-nitrobutanyl methylsulfonyl ether | HCID 86750300 | — |
반응 단계
A 3.5 g sample of the alcohol from step 471a above was dissolved in 25 mL of methylene chloride and treated with methanesulfonyl chloride an TEA at 0° C. for 2 hours. The reaction mixture was washed with NaHCO3 solution and water, and the solvent was removed. The residue was chromatographed on silica gel to give 3 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05726182 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-d35336a8d63f46faa12cbe3c8194e4f3 |
| 출처 메모 | uspto-grants-1998_03 |