5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-2-benzofuran-1-one → 5-[5-Fluoro-4-(1-hydroxy-ethyl)-pyridin-3-yl]-3H-Isobenzofuran-1-one

반응식

CC1(C)C(C)(C)OB([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[C:14](=[O:18])[O:13][CH2:12]3)O1.Br[C:21]1[CH:22]=[N:23][CH:24]=[C:25]([F:30])[C:26]=1[CH:27]([OH:29])[CH3:28]>>[F:30][C:25]1[C:26]([CH:27]([OH:29])[CH3:28])=[C:21]([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[C:14](=[O:18])[O:13][CH2:12]3)[CH:22]=[N:23][CH:24]=1

참가 물질

반응물 2

HCID 580746235-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-2-benzofuran-1-one

HCID 699379091-(3-Bromo-5-Fluoro-pyridin-4-yl)-ethanol

생성물 1

HCID 699375155-[5-Fluoro-4-(1-hydroxy-ethyl)-pyridin-3-yl]-3H-Isobenzofuran-1-one

실험 절차

5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-3H-isobenzofuran-1-one and 1-(3-bromo-5-fluoro-pyridin-4-yl)-ethanol were reacted according to the procedure described in Example 35.

출처 및 근거

ORD 기록: ord-6645e1fb2f2f4b3b9995485a645bd34b
출처 데이터셋: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08519134B2

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