Acetyl chloride → n-(5-Methoxy-2-methylphenyl)acetamide
반응식
C(N(CC)CC)C.[CH3:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([CH3:17])=[C:14]([CH:16]=1)[NH2:15].[C:18](Cl)(=[O:20])[CH3:19]>C(Cl)Cl>[CH3:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([CH3:17])=[C:14]([NH:15][C:18](=[O:20])[CH3:19])[CH:16]=1참가 물질
5
실험 절차
To a solution of triethylamine (2.9 g, 14.4 mmol) and 5-methoxy-2-methylaniline (1.0 g, 7.2 mmol) in DCM (30 mL) at 0° C., was added acetyl chloride (0.57 g, 7.2 mmol) dropwise. The mixture was stirred at room temperature for 1 hour. The reaction was quenched with saturated ammonium chloride aqueous solution, and extracted with DCM. The organic layer was dried over Na2SO4 and concentrated to give N-(5-methoxy-2-methylphenyl)acetamide as needle-shaped crystals. The crude product was used in the next step without further purification.
후처리
- customThe reaction was quenched with saturated ammonium chloride aqueous solution
- extractionextracted with DCM
- dry with materialThe organic layer was dried over Na2SO4
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-308b3493c5904aa893672847f6a87713
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08519129B2
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