Ammonia → HCID 59578441, 화합물

반응식

C[O:2][C:3](=O)[CH2:4][CH2:5][C:6]1[CH:7]=[N:8][CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:13]=2[Cl:19])[CH:11]=1.[NH3:21]>>[Cl:19][C:13]1[C:14]([Cl:18])=[CH:15][CH:16]=[CH:17][C:12]=1[C:10]1[CH:11]=[C:6]([CH2:5][CH2:4][C:3]([NH2:21])=[O:2])[CH:7]=[N:8][CH:9]=1

참가 물질

반응물 2

HCID 222Ammonia2회

HCID 595784053-[5-(2,3-Dichloro-phenyl)-pyridin-3-yl]-propionic acid methyl ester

생성물 1

HCID 59578441HCID 59578441, 화합물

실험 절차

A mixture of 3-[5-(2,3-dichloro-phenyl)-pyridin-3-yl]-propionic acid methyl ester and ammonia (7N in MeOH, 2 ml, 14.00 mmol) was stirred at room temperature for 24 hours. Ammonia (7N in MeOH, 1 ml, 7.00 mmol) was added, and the reaction mixture was stirred for another 24 hours. Solvent was removed in vacuo. The crude product was used in the next step without purification. ESI-MS m/z: 295 [M+1]+.

후처리

stirringthe reaction mixture was stirred for another 24 hours
customSolvent was removed in vacuo
customThe crude product was used in the next step without purification

출처 및 근거

ORD 기록: ord-a3fc54d7c3904939a4e591ac30b719b2
출처 데이터셋: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08519142B2

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