Trifluoroacetic acid → 3-Methylazetidine-3-carbonitrile; trifluoroacetic acid

HRID 1898507노트

반응식

HRID 1898507 반응식
C(OC([N:8]1[CH2:11][C:10]([C:13]#[N:14])([CH3:12])[CH2:9]1)=O)(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18].[C:13]([C:10]1([CH3:12])[CH2:11][NH:8][CH2:9]1)#[N:14]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 56971684tert-Butyl 3-cyano-3-methylazetidine-1-carboxylate

생성물 1

HCID 673862343-Methylazetidine-3-carbonitrile; trifluoroacetic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-Cyano-3-methyl-azetidine-1-carboxylic acid tert-butyl ester (0.23 g, 1.17 mmol) was dissolved in 12 mL of dichloromethane and the reaction was then stirred in an ice bath. Trifluoroacetic acid (3.6 mL) was added slowly and the solution was warmed to room temperature. After 3 h the reaction mixture was evaporated to afford 3-cyano-3-methyl-azetidine trifluoroacetate which was used without further purification.

후처리

  1. customAfter 3 h the reaction mixture was evaporated

출처 및 근거

ORD 기록
ord-45e78b1486e74e1face942ff5f37f8b0
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518945B2

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